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Norditropin SimpleXx 15 mg/1.5 ml, solution for injection in cartridge
Solution for injection in cartridge
Solution for injection in pre-filled pen
Clear, colourless solution
Pharmacotherapeutic group: Somatropin and somatropin agonists. ATC: H01AC01.
Mechanism of action
Norditropin SimpleXx / Norditropin NordiFlex contains somatropin, which is human growth hormone produced by recombinant DNA-technology. It is an anabolic peptide of 191 amino acids stabilised by two disulphide bridges with a molecular weight of approximately 22,000 Daltons.
The major effects of somatropin are stimulation of skeletal and somatic growth and pronounced influence on the body's metabolic processes.
When growth hormone deficiency is treated a normalisation of body composition takes place resulting in an increase in lean body mass and a decrease in fat mass.
Somatropin exerts most of its actions through insulin-like growth factor 1 (IGF-1), which is produced in tissues throughout the body but predominantly by the liver.
More than 90% of IGF-1 is bound to binding proteins (IGFBPs) of which IGFBP-3 is the most important.
A lipolytic and protein sparing effect of the hormone becomes of particular importance during stress.
Somatropin also increases bone turnover indicated by an increase in plasma levels of biochemical bone markers. In adults bone mass is slightly decreased during the initial months of treatment due to more pronounced bone resorption, however, bone mass increases with prolonged treatment.